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The dry eye model was established in group Fin and group Bp.
Aqueous tear quantity was measured with phenol red-impregnated cotton threads with anesthesia.
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My objective in this ongoing work is to determine how this heterogeneity in clinical features translates to molecular differences between men and women with psychiatric illnesses.
Methods: We recruited men and women with Asperger syndrome, schizophrenia, bipolar disorder, major depressive disorder, as well as healthy controls from a number of clinics across Europe.
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Animals were sacrificed at 28 days, and ocular tissues (lacrimal gland and cornea) were evaluated with light microscopy; gene microarray analysis for inflammatory cytokines and Western blot were also performed.
Each spot represents an AS (red) or control (black) subject.
The model built on males using 24 AS male-specific analytes (left) does not yield a separation in prediction of AS in females (right).
On the other hand, women are generally diagnosed with schizophrenia at an older age compared to men and they show a better response to antipsychotic treatment with a more favourable course of illness (at least, prior to menopause).
Figure 1 illustrates a number of distinct and overlapping sex differences in clinical features across a selection of these disorders. A summary of distinct and overlapping gender differences present in autism spectrum disorders (ASD), schizophrenia (SCZ), bipolar disorder (BD) and major depressive disorder (MDD).